An electroencephalogram (EEG) is used to measure the electrical activity of your brain. Typically, it is done by placing small electrodes on your scalp, and the resulting brain waves are recorded and interpreted by a healthcare professional. EEGs are useful in detecting a number of brain-related conditions, such as epilepsy, sleep-related disorders, or stroke, among others.

At Neuraura, we provide proprietary micro-electrodes that are capable of producing world-class high fidelity EEG data to make unlocking brain insights easier.

An electrocorticography (ECOG) is a type of sensor which can be used to provide an image of the brain. This enables the brain to be monitored, and professionals are able to comprehend and locate certain electrical stimulations which can help to study certain brain-related conditions.

Neuromodulation is the use of technology to alter nerve activity, usually with either electrical or chemical stimulation to a targeted neurological area. It is used to help treat a variety of ailments, including neurological disorders, such as Parkinson’s Disease or epilepsy, psychiatric conditions, such as depression or anxiety, as well as sensory disorders, such as chronic pain or pelvic disorders.

With personalized brain care, patients will be able to receive treatment that is tailored to them. By mapping out key target neurological regions, specialists will be able to individually stimulate each area to identify the most effective treatment sites. These areas may differ between individuals, which is why personalized care is important.

For epilepsy surgery, clinicians have poor information on which to base

decisions on where to resect brain tissue (and leading to subsequent high resurgence rates) and the patient experience is especially poor due to being “wired” within the specialist recording unit for 1-6 weeks limiting the uptake of surgery to less than 10% of those who are diagnosed with refractory epilepsy each year.

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For neuromodulation devices, not only does the paucity of brain insight result in low efficacy (c. 50% in some first-generation devices) but also poor precision in stimulation resulting in tissue damage and limiting the longevity of the implant and ultimately the viable clinical use cases.

Our core technological advantage is our sensor technology. Pierre and Colin improved the performance over many iterations over the course of Pierre’s PhD. The low noise performance is achieved through the use of 3-dimensional electrode structures and an insulation coating. Both the sensor design and assembly will be protected by patents and the exact composition of the coating is a trade secret.

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As a result, Neuraura achieved the following performance in in-house trials:

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• 100% seizure detection

• 3x signal to noise ratio compared to research-grade stainless steel electrodes

• 20x spatial resolution compared to traditional Electrocorticography (ECOG) sensors

• 350x smaller compared to traditional ECOG

Neuraura has the potential to improve the lives of millions of people suffering from neurological, psychiatric and sensory conditions and to enhance human performance through prosthetics, cognitive enhancement and braincomputer communication. This potential is what ultimately drives the team with success defined by people positively impacted as a result of our technology. This includes patients, their families and society as a whole.

The sensor networks and corresponding data insights are a platform

technology with a multitude of applications, for example:

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• Prediction and treatment of neurological, psychiatric and sensory

conditions

• Enhancement of communication, control and cognitive function

• In-vivo and in-vitro research and drug screening (general and

personalized to cell tissue)

• Other non-brain clinical applications, e.g., cardio vascular

• Non-human clinical applications

• Other non-medical applications